IL-4Ra/NOS2

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
IL-4Ra/NOS2
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
400 sporozoites
Mouse genetic background (Con): 
BALB/c
Level of backcrossing: 
Pure strain (100%)
Experimental treatment group (EG): 
IL-4Ra -/- + NOS2 inhibitor
Lethal infection (Con): 
yes
Lethal infection (EG): 
80-100%
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Decreased compared to NOS2 inhibitor treated WT BALB/c mice
Additional phenotypes (EG vs Con): 
N.I.
Refs: 
Saeftel et al., 2004, Infect Immun