GM-CSF

Molecular group: 
Cytokines and receptors
Molecule/Cell: 
GM-CSF
Plasmodium strain: 
Plasmodium chabaudi chabaudi AS
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
129/Ola x C57BL/6
Level of backcrossing: 
N.I.
Experimental treatment group (EG): 
GM-CSF -/-
Lethal infection (Con): 
no
Lethal infection (EG): 
♂ 75 %; ♀ 46 %
Pathology (Con): 
Anemia
Pathology (EG): 
Anemia
Parasitemia (EG vs Con): 
Increased peak and increased recrudescences
Additional phenotypes (EG vs Con): 
↓ splenomegaly; ↓ leukocytosis (↓ number of macrophages, lymphocytes and similar granulocytes); similar anemia and erythropoiesis; ↑ serum TNF-a and IFN-g (↑ serum IFN-g also in uninfected KO mice compared to uninfected WT mice)
Refs: 
Riopel et al., 2001, Infect Immun