Mouse expression


The effects of malaria infection on expression levels (mRNA and protein) of cytokines, chemokines, enzymes, adhesion molecules, angiogenic and coagulation factors, metabolic molecules, etc. in different organs and body fluids of mice infected with different rodent malaria species are listed in this part of the database. For each molecule, information about the genetic background of the mouse strain, parasite species, inoculum size (pRBC), references (Refs), and a hyperlink to the original paper in the PubMed database (U.S. National Library of Medicine, National Institutes of Health) is included.

Dynamic fields: these are the columns that you can select to show in the output table. See also "How to use MalarImDB?" for more information.

Abbreviations: A, activity; ND, not detectable; N.I., not indicated; ns, not significant; ↑d, increased levels on day x (example1: ↑d4-8: levels increase from day 4 postinfection until day 8 postinfection; example2: ↑d4-…: levels increase from day 4 postinfection until end of observation time; example3: ↑d4, d8: levels are increased on day 4 postinfection and on day 8 postinfection)↓, decreased levels; →, similar levels (no changes)

 

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Full
Molecular group
Molecule/Cell
Plasmodium strain
pRBC infection titer
Mouse genetic background (Con)
Spleen mRNA
Spleen Protein
Liver mRNA
Liver protein
Brain mRNA
Brain protein
Lung mRNA
Lung protein
Kidney mRNA
Kidney protein
Heart protein
Pancreas protein
Mesentery protein
Thymus protein
Serum/plasma protein
Refs
PubMed
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Full Molecule/Cell Plasmodium strain Mouse genetic background (Con) Spleen mRNA Spleen Protein Liver mRNA Liver protein Brain mRNA Brain protein Lung mRNA Lung protein Kidney mRNA Kidney protein Serum/plasma protein Refs PubMed
EPO Plasmodium berghei ANKA CBA/T6 ns Rae et al., 2004, FASEB J Link
EPO Plasmodium berghei K173 CBA/T6 ns Rae et al., 2004, FASEB J Link
EPO Plasmodium yoelii 17XNL C57BL/6 ↑d21 ↑d7-21 Halder et al., 2003, Parasitol Int Link
EPO-R Plasmodium berghei ANKA CBA/T6 ↓d5-6 Rae et al., 2004, FASEB J Link
EPO-R Plasmodium berghei K173 CBA/T6 → Rae et al., 2004, FASEB J Link
Factor VII Plasmodium berghei ANKA C57BL/6 → Van der Heyde et al., 2005, Blood Link
Fas Plasmodium berghei ANKA C57BL/6 → ↑d6 Potter et al., 2006, J Neuroimmunol Link
Fas Plasmodium berghei K173 C57BL/6 → ↑d10 Potter et al., 2006, J Neuroimmunol Link
FasL Plasmodium berghei ANKA C57BL/6 ↑d6 Miu et al., 2008, J Immunol Link
FasL Plasmodium berghei ANKA C57BL/6 → ↑d5-6 Potter et al., 2006, J Neuroimmunol Link
FasL Plasmodium berghei K173 C57BL/6 → → Potter et al., 2006, J Neuroimmunol Link
FasL Plasmodium berghei NK65 C57BL/6 ↑d4-8 ↑d4-12 Yoshimoto et al., 1998, J Immunol Link
Fibrinogen Plasmodium berghei ANKA C57BL/6 → Van der Heyde et al., 2005, Blood Link
Glutamate Plasmodium berghei ANKA C57BL/6 ↑d4-6 Chang et al., 2001, Infect Immun Link
Glutamate Plasmodium berghei ANKA C57BL/6 ↓d6-7 Parekh et al., 2006, Int J Parasitol Link
Glutamate Plasmodium berghei ANKA CBA/T6 ↓d7 Sanni et al., 1998, Am J Pathol Link
Glutamate Plasmodium berghei K173 CBA/T6 → Sanni et al., 1998, Am J Pathol Link
Glutamate dehydrogenase Plasmodium berghei ANKA CBA/T6 → Rae et al., 2004, FASEB J Link
Glutamate dehydrogenase Plasmodium berghei K173 CBA/T6 ↓d1-11 Rae et al., 2004, FASEB J Link
Glutamine synthetase Plasmodium berghei ANKA CBA/T6 A ↓d6-7 Sanni et al., 1999, J Infect Dis Link
Glutamine synthetase Plasmodium berghei K173 CBA/T6 ↑d2-7 Rae et al., 2004, FASEB J Link
Glutamine synthetase Plasmodium berghei K173 CBA/T6 A → Sanni et al., 1999, J Infect Dis Link
Glycine Plasmodium berghei ANKA C57BL/6 → Chang et al., 2001, Infect Immun Link
Granzyme B Plasmodium berghei ANKA C57BL/6 ↑d6 Coban et al., 2007, Int Immunol Link
Granzyme B Plasmodium berghei ANKA C57BL/6 → ↑d5-6 Potter et al., 2006, Int J Parasitol Link
Granzyme B Plasmodium berghei ANKA C57BL/6 ↑d5-6 Potter et al., 2006, J Neuroimmunol Link
Granzyme B Plasmodium berghei K173 C57BL/6 → → Potter et al., 2006, Int J Parasitol Link
HIF-1a Plasmodium berghei ANKA C57BL/6 ↑d7 Hempel et al., 2011, Am J Pathol Link
HIF-1a Plasmodium berghei ANKA CBA/T6 → Rae et al., 2004, FASEB J Link
HIF-1a Plasmodium berghei K173 C57BL/6 → Hempel et al., 2011, Am J Pathol Link
HIF-1a Plasmodium berghei K173 CBA/T6 → Rae et al., 2004, FASEB J Link
Histamine Plasmodium berghei (N.I.) Albino → Roy et al., 1993, Indian J Malariol Link
Histamine Plasmodium berghei ANKA C57BL/6 ↑d7 ↑d5-8 Beghdadi et al., 2008, J Exp Med Link
Histamine Plasmodium berghei NK65 C57BL/6 ↑d21 Beghdadi et al., 2008, J Exp Med Link
Histidine de-carboxylase (HDC) Plasmodium berghei ANKA C57BL/6 ↑d3-6 Beghdadi et al., 2009, PLoS One Link
HMGB1 Plasmodium berghei ANKA C57BL/6 ↑d5 Higgins et al., 2013, Malar J Link
Hmox1/HO-1 Plasmodium berghei ANKA BALB/c ↑d6 ↑d9-12 Pamplona et al., 2007, Nat Med Link
Hmox1/HO-1 Plasmodium berghei ANKA C57BL/6 → Pamplona et al., 2007, Nat Med Link
Hmox1/HO-1 Plasmodium chabaudi chabaudi AS BALB/c ↑d6-7 Seixas et al., 2009, Proc Natl Acad Sci U S A Link
HO-2 Plasmodium berghei ANKA BALB/c → Pamplona et al., 2007, Nat Med Link
HO-2 Plasmodium chabaudi chabaudi AS BALB/c → Seixas et al., 2009, Proc Natl Acad Sci U S A Link
Homoarginine Plasmodium berghei ANKA C57BL/6 ↓d4-6 Gramaglia et al., 2006, Nat Med Link
Iba1 Plasmodium berghei ANKA C57BL/6 ↑d6 Kennan et al., 2005, Parasitol Res Link
IFN-g Plasmodium berghei ANKA (BALB/c x C57BL/6) F1 ↑d5-15 De Souza et al., 1997, Infect Immun Link
IFN-g Plasmodium berghei ANKA 129Sv/Ev ↑d7 ↑d7 ↑d7 ↑d7 ↑d7 Amani et al., 2000, Eur J Immunol Link
IFN-g Plasmodium berghei ANKA BALB/c ↑d7 → De Kossodo et al., 1993, J Immunol Link
IFN-g Plasmodium berghei ANKA BALB/c ↑d1-9 ↑d9 Chen et al., 2000, Clin Exp Immunol Link
IFN-g Plasmodium berghei ANKA BALB/c ↑d5 Hansen et al., 2005, Infect Immun Link
IFN-g Plasmodium berghei ANKA BALB/c ↑d5 Hansen et al., 2003, Immunity Link
IFN-g Plasmodium berghei ANKA BALB/c ↑d3 ↑d7 ↑d5 Singh et al., 2002, J Immunol Link
IFN-g Plasmodium berghei ANKA BALB/c ↑d8 Van den steen et al., 2008, Eur J Immunol Link
IFN-g Plasmodium berghei ANKA BALB/c → d3 Saeftel et al., 2004, Infect Immun Link
IFN-g Plasmodium berghei ANKA C57BL/6 ↑d6 Miu et al., 2008, J Immunol Link
IFN-g Plasmodium berghei ANKA C57BL/6 ↑d6 Pamplona et al., 2007, Nat Med Link
IFN-g Plasmodium berghei ANKA C57BL/6 ↑d5 Randall et al., 2008, Infect Immun Link
IFN-g Plasmodium berghei ANKA C57BL/6 ↑d5 Srivastava et al., 2008, Cell Host Microbe Link
IFN-g Plasmodium berghei ANKA C57BL/6 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
IFN-g Plasmodium berghei ANKA C57BL/6 ↑ at time of CM Vigário et al., 2007, J Immunol Link
IFN-g Plasmodium berghei ANKA C57BL/6 ↑d8 Wiese et al., 2008, Malar J Link
IFN-g Plasmodium berghei ANKA C57BL/6 ↑d5-6 Finney et al., 2009, Am J Trop Med Hyg Link
IFN-g Plasmodium berghei ANKA C57BL/6 ↑d4-8 ↑d4-8 ↑d8 ↑d4-8 Tan et al., 1999, Infect Immun Link
IFN-g Plasmodium berghei ANKA C57BL/6 → De Miranda et al., 2011, Neurosci Lett Link
IFN-g Plasmodium berghei ANKA C57BL/6 ↑d5 Higgins et al., 2013, Malar J Link
IFN-g Plasmodium berghei ANKA C57BL/6 ↑d4 Van der Heyde et al., 2005, Blood Link
IFN-g Plasmodium berghei ANKA C57BL/6 ↑d5 Beghdadi et al., 2008, J Exp Med Link
IFN-g Plasmodium berghei ANKA C57BL/6 ↑d6-8 ↑d6-8 Campanella et al., 2008, Proc Natl Acad Sci U S A Link
IFN-g Plasmodium berghei ANKA C57BL/6 ↑d7 Favre et al., 1999, Microbes Infect Link
IFN-g Plasmodium berghei ANKA C57BL/6 ↑d5 Hansen et al., 2003, Immunity Link
IFN-g Plasmodium berghei ANKA C57BL/6 ↑d2-4 ↑d2-6 ↑d3-4 Mitchell et al., 2005, Infect Immun Link
IFN-g Plasmodium berghei ANKA C57BL/6 x 129 ↑d4, d8 Lucas et al., 1997, Eur J Immunol Link
IFN-g Plasmodium berghei ANKA C57BL/6J ↑d5 Morrell et al., 2011, Infect Immun Link
IFN-g Plasmodium berghei ANKA C57BL/6J x 129/Ola ↑d7-10 (when CM symptoms manifested) Belnoue et al., 2003, Blood Link
IFN-g Plasmodium berghei ANKA CBA ↑d5 Randall et al., 2008, Infect Immun Link
IFN-g Plasmodium berghei ANKA CBA ↑d6 Ball et al., 2004, J Infect Dis Link
IFN-g Plasmodium berghei ANKA CBA/J ↑d6-7 Kaiser et al., 2006, J Infect Dis Link
IFN-g Plasmodium berghei ANKA CBA/J ↑d7 ↑d7 De Kossodo et al., 1993, J Immunol Link
IFN-g Plasmodium berghei ANKA CBA/J ↑d7 ↑d7 De Kossodo et al., 1993, J Immunol Link
IFN-g Plasmodium berghei ANKA CBA/NSlc ↑d1, d9 ↑d9 Chen et al., 2000, Clin Exp Immunol Link
IFN-g Plasmodium berghei ANKA CBA/T6 ↑d6 Rae et al., 2004, FASEB J Link
IFN-g Plasmodium berghei ANKA DBA/1 ↑d10 Van den steen et al., 2008, Eur J Immunol Link
IFN-g Plasmodium berghei ANKA DBA/2 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
IFN-g Plasmodium berghei ANKA + K173 C57BL/6 ↑d1 ↑d1 Mitchell et al., 2005, Infect Immun Link
IFN-g Plasmodium berghei ANKA 6653 Swiss Albino ↑d7 Dogruman-Al et al., 2009, New Microbiol Link
IFN-g Plasmodium berghei K173 C57BL/6 ↑d1, d4-6 ↑d1, 4-... ↑d1, d4-… Mitchell et al., 2005, Infect Immun Link
IFN-g Plasmodium berghei K173 CBA ↑d14 Ball et al., 2004, J Infect Dis Link
IFN-g Plasmodium berghei K173 CBA/T6 ↑d14 Rae et al., 2004, FASEB J Link
IFN-g Plasmodium berghei NK65 BALB/c ↑d6-8, d14, d20 Ishih et al., 2008, Southeast Asian J Trop Med Public Health Link
IFN-g Plasmodium berghei NK65 BALB/c ↑d3-10 Omer et al., 1998, J Exp Med Link
IFN-g Plasmodium berghei NK65 C57BL/6 ↑d2-12 ↑d4-8 Yoshimoto et al., 1998, J Immunol Link
IFN-g Plasmodium berghei NK65 C57BL/6J ↑d8-12 Van den steen et al., 2010, Am J Respir Crit Care Med Link
IFN-g Plasmodium berghei XAT CBA/JNCrj ↑d4-9 ↑d4 Yoshimoto et al., 1998, J Infect Dis Link
IFN-g Plasmodium chabaudi chabaudi AS (BALB/c x C57BL/6) F1 ↑d7-12 De Souza et al., 1997, Infect Immun Link
IFN-g Plasmodium chabaudi chabaudi AS 129/Sv ↑d7-9 Taylor et al., 2001, Infect Immun Link
IFN-g Plasmodium chabaudi chabaudi AS A/J ↑d5 Jacobs et al., 1996, Infect Immun Link
IFN-g Plasmodium chabaudi chabaudi AS A/J ND Stevenson et al., 1995, J Immunol Link
IFN-g Plasmodium chabaudi chabaudi AS B10.D2 ↑d2-8 ↑d6-8 Cross et al., 1998, Exp Parasitol Link
IFN-g Plasmodium chabaudi chabaudi AS BALB/c ↑d6 ↑d6-8 Tsutsui et al., 1999, Infect Immun Link
IFN-g Plasmodium chabaudi chabaudi AS C57BL/10 ↑d6-8 ↑d5-9 Tsutsui et al., 1999, Infect Immun Link
IFN-g Plasmodium chabaudi chabaudi AS C57BL/6 ↑d6-7 Labbé et al., 2010, J Immunol Link
IFN-g Plasmodium chabaudi chabaudi AS C57BL/6 ↑d6-8 Clark et al., 2007, Parasite Immunol Link

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