Mouse expression


The effects of malaria infection on expression levels (mRNA and protein) of cytokines, chemokines, enzymes, adhesion molecules, angiogenic and coagulation factors, metabolic molecules, etc. in different organs and body fluids of mice infected with different rodent malaria species are listed in this part of the database. For each molecule, information about the genetic background of the mouse strain, parasite species, inoculum size (pRBC), references (Refs), and a hyperlink to the original paper in the PubMed database (U.S. National Library of Medicine, National Institutes of Health) is included.

Dynamic fields: these are the columns that you can select to show in the output table. See also "How to use MalarImDB?" for more information.

Abbreviations: A, activity; ND, not detectable; N.I., not indicated; ns, not significant; ↑d, increased levels on day x (example1: ↑d4-8: levels increase from day 4 postinfection until day 8 postinfection; example2: ↑d4-…: levels increase from day 4 postinfection until end of observation time; example3: ↑d4, d8: levels are increased on day 4 postinfection and on day 8 postinfection)↓, decreased levels; →, similar levels (no changes)

 

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Full
Molecular group
Molecule/Cell
Plasmodium strain
pRBC infection titer
Mouse genetic background (Con)
Spleen mRNA
Spleen Protein
Liver mRNA
Liver protein
Brain mRNA
Brain protein
Lung mRNA
Lung protein
Kidney mRNA
Kidney protein
Heart protein
Pancreas protein
Mesentery protein
Thymus protein
Serum/plasma protein
Refs
PubMed
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Full Molecule/Cell Plasmodium strain Mouse genetic background (Con) Spleen mRNA Spleen Protein Liver mRNA Liver protein Brain mRNA Brain protein Lung mRNA Lung protein Kidney mRNA Kidney protein Serum/plasma protein Refs PubMed
CCL3 (MIP-1a) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCL3 (MIP-1a) Plasmodium berghei K173 CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCL3/4 (MIP-1) Plasmodium berghei ANKA C57BL/6 ↑d10 Labbé et al., 2010, J Immunol Link
CCL4 (MIP-1b) Plasmodium berghei ANKA BALB/c ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CCL4 (MIP-1b) Plasmodium berghei ANKA C57BL/6 ↑d8 ↑d8 Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CCL4 (MIP-1b) Plasmodium berghei ANKA C57BL/6 ↑d6-8 Van den steen et al., 2008, Eur J Immunol Link
CCL4 (MIP-1b) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCL4 (MIP-1b) Plasmodium berghei ANKA DBA/1 ↑d10 Van den steen et al., 2008, Eur J Immunol Link
CCL4 (MIP-1b) Plasmodium berghei ANKA DBA/2 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CCL4 (MIP-1b) Plasmodium berghei K173 CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCL5 (RANTES) Plasmodium berghei ANKA BALB/c → ↑d6-8 ↑d6-8 Hanum et al., 2003, Int Immunol Link
CCL5 (RANTES) Plasmodium berghei ANKA BALB/c ↑d6-8 Van den steen et al., 2008, Eur J Immunol Link
CCL5 (RANTES) Plasmodium berghei ANKA C57BL/6 ↓d8 ↑d8 Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CCL5 (RANTES) Plasmodium berghei ANKA C57BL/6 → ↑d8 ↑d4-8 Hanum et al., 2003, Int Immunol Link
CCL5 (RANTES) Plasmodium berghei ANKA C57BL/6 ↑d6-8 Van den steen et al., 2008, Eur J Immunol Link
CCL5 (RANTES) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCL5 (RANTES) Plasmodium berghei ANKA DBA/1 ↑d10 Van den steen et al., 2008, Eur J Immunol Link
CCL5 (RANTES) Plasmodium berghei ANKA DBA/2 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CCL5 (RANTES) Plasmodium berghei K173 CBA/T6 ↑d6, d14 Miu et al., 2008, J Immunol Link
CCL5 (RANTES) Plasmodium berghei NK65 C57BL/6 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CCL5 (RANTES) Plasmodium yoelii 17XL SW ↑d4-8 ↑d4-8 ↑d4-8 Sarfo et al., 2005, Malar J Link
CCL6 (MRP-1) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCL6 (MRP-1) Plasmodium berghei K173 CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCL7 (MARC, MCP-3?) Plasmodium berghei ANKA C57BL/6 ↑d8 ↑d8 Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CCL7 (MARC, MCP-3?) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCL7 (MARC, MCP-3?) Plasmodium berghei K173 CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCL8 (MCP-2?) Plasmodium berghei ANKA C57BL/6 ↑d8 → Campanella et al., 2008, Proc Natl Acad Sci U S A Link
CCL8 (MCP-2?) Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCL8 (MCP-2?) Plasmodium berghei K173 CBA/T6 ↑d6, d14 Miu et al., 2008, J Immunol Link
CCL9 (MIP-1g) Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CCL9 (MIP-1g) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CCR1 Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCR1 Plasmodium berghei K173 CBA/T6 ↑d6, d14 Miu et al., 2008, J Immunol Link
CCR1 Plasmodium yoelii 17XL SW ↑d6-8 Sarfo et al., 2005, Malar J Link
CCR2 Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCR2 Plasmodium berghei K173 CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCR3 Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CCR3 Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CCR3 Plasmodium yoelii 17XL SW ↑d6-8 Sarfo et al., 2005, Malar J Link
CCR4 Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CCR4 Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CCR5 Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCR5 Plasmodium berghei K173 CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCR5 Plasmodium yoelii 17XL SW ↑d6-8 Sarfo et al., 2005, Malar J Link
CCR6,9,10,11 Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
CCR6,9,10,11 Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CCR7,8 Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
CCR7,8 Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
CD102 (ICAM-2) Plasmodium berghei ANKA C57BL/6 → → → → Li et al., 2003, J Investig Med Link
CD106 (VCAM-1) Plasmodium berghei ANKA BALB/c → Van den steen et al., 2008, Eur J Immunol Link
CD106 (VCAM-1) Plasmodium berghei ANKA C57BL/6 ↑d7 Beghdadi et al., 2008, J Exp Med Link
CD106 (VCAM-1) Plasmodium berghei ANKA C57BL/6 ↑d6 Pamplona et al., 2007, Nat Med Link
CD106 (VCAM-1) Plasmodium berghei ANKA C57BL/6 ↑d4-6 ↑d4-6 ↑d4-6 ↑d6 Bauer et al., 2002, Microcirculation Link
CD106 (VCAM-1) Plasmodium berghei ANKA C57BL/6J → Van den steen et al., 2008, Eur J Immunol Link
CD106 (VCAM-1) Plasmodium berghei ANKA DBA/1 → Van den steen et al., 2008, Eur J Immunol Link
CD106 (VCAM-1) Plasmodium berghei ANKA DBA/2 → Van den steen et al., 2008, Eur J Immunol Link
CD11a/CD18 (LFA-1) Plasmodium berghei ANKA BALB/c ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CD11a/CD18 (LFA-1) Plasmodium berghei ANKA C57BL/6 → ↑d6 Potter et al., 2006, Int J Parasitol Link
CD11a/CD18 (LFA-1) Plasmodium berghei ANKA C57BL/6 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CD11a/CD18 (LFA-1) Plasmodium berghei ANKA DBA/1 ↑d10 Van den steen et al., 2008, Eur J Immunol Link
CD11a/CD18 (LFA-1) Plasmodium berghei ANKA DBA/2 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CD11a/CD18 (LFA-1) Plasmodium berghei K173 C57BL/6 → → Potter et al., 2006, Int J Parasitol Link
CD31 (PECAM-1) Plasmodium berghei ANKA BALB/c ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CD31 (PECAM-1) Plasmodium berghei ANKA C57BL/6 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CD31 (PECAM-1) Plasmodium berghei ANKA DBA/1 ↑d10 Van den steen et al., 2008, Eur J Immunol Link
CD31 (PECAM-1) Plasmodium berghei ANKA DBA/2 → Van den steen et al., 2008, Eur J Immunol Link
CD4 Plasmodium berghei ANKA C57BL/6 → → Potter et al., 2006, Int J Parasitol Link
CD4 Plasmodium berghei ANKA C57BL/6 → → Potter et al., 2006, J Neuroimmunol Link
CD4 Plasmodium berghei K173 C57BL/6 → → Potter et al., 2006, Int J Parasitol Link
CD40 Plasmodium berghei ANKA C57BL/6J → ↑d7-8 ↑d7-8 Piguet et al., 2002, Lab Invest Link
CD40 Plasmodium berghei ANKA C57BL/6J → ↑d7 ↑d7 Piguet et al., 2001, Am J Pathol Link
CD40L Plasmodium berghei ANKA C57BL/6 → → ↑d7 Piguet et al., 2001, Am J Pathol Link
CD54 (ICAM-1) Plasmodium berghei ANKA BALB/c ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CD54 (ICAM-1) Plasmodium berghei ANKA BALB/c ↓d6 → ↑d6 ↑d6 → Li et al., 2003, J Investig Med Link
CD54 (ICAM-1) Plasmodium berghei ANKA C57BL/6 ↑d7 Beghdadi et al., 2008, J Exp Med Link
CD54 (ICAM-1) Plasmodium berghei ANKA C57BL/6 ↑d6 Miu et al., 2008, J Immunol Link
CD54 (ICAM-1) Plasmodium berghei ANKA C57BL/6 ↑d6 Pamplona et al., 2007, Nat Med Link
CD54 (ICAM-1) Plasmodium berghei ANKA C57BL/6 → ↑d6 Potter et al., 2006, Int J Parasitol Link
CD54 (ICAM-1) Plasmodium berghei ANKA C57BL/6 ↑d4-6 ↑d6 ↑d6 ↑d6 Bauer et al., 2002, Microcirculation Link
CD54 (ICAM-1) Plasmodium berghei ANKA C57BL/6 → ↑d4-6 ↑d6 ↑d4-6 → Li et al., 2003, J Investig Med Link
CD54 (ICAM-1) Plasmodium berghei ANKA C57BL/6 x 129 ↑d8 ↑d8 Lucas et al., 1997, J Neuroimmunol Link
CD54 (ICAM-1) Plasmodium berghei ANKA C57BL/6J ↑d7-8 (ns?) ↑d7-8 ↑d7-8 Piguet et al., 2002, Lab Invest Link
CD54 (ICAM-1) Plasmodium berghei ANKA C57BL/6J → ↑d7 ↑d7 Piguet et al., 2001, Am J Pathol Link
CD54 (ICAM-1) Plasmodium berghei ANKA C57BL/6J ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CD54 (ICAM-1) Plasmodium berghei ANKA DBA/1 ↑d10 Van den steen et al., 2008, Eur J Immunol Link
CD54 (ICAM-1) Plasmodium berghei ANKA DBA/2 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CD54 (ICAM-1) Plasmodium berghei K173 C57BL/6 → → Potter et al., 2006, Int J Parasitol Link
CD54 (ICAM-1) Plasmodium yoelii 17XL SW ↑d4-5, d8 Shear et al., 1998, Am J Trop Med Hyg Link
CD54 (ICAM-1) Plasmodium yoelii 17XNL SW ↑d5, d7, d9 Shear et al., 1998, Am J Trop Med Hyg Link
CD62E (E-selectin) Plasmodium berghei ANKA C57BL/6 → → → ↓d6 Bauer et al., 2002, Microcirculation Link
CD62P (P-selectin) Plasmodium berghei ANKA BALB/c ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CD62P (P-selectin) Plasmodium berghei ANKA BALB/c ↑d6 ↑d6 ↑d6 Chang et al., 2003, Infect Immun Link
CD62P (P-selectin) Plasmodium berghei ANKA C57BL/6 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CD62P (P-selectin) Plasmodium berghei ANKA C57BL/6 ↑d4-6 ↑d6 ↑d4-6 ns Bauer et al., 2002, Microcirculation Link
CD62P (P-selectin) Plasmodium berghei ANKA C57BL/6 ↑d6 ↑d4-6 ↑d4-6 Chang et al., 2003, Infect Immun Link
CD62P (P-selectin) Plasmodium berghei ANKA DBA/1 ↑d10 Van den steen et al., 2008, Eur J Immunol Link
CD62P (P-selectin) Plasmodium berghei ANKA DBA/2 ↑d8 Van den steen et al., 2008, Eur J Immunol Link
CD8 Plasmodium berghei ANKA C57BL/6 → ↑d5-6 ↑d3-6 Potter et al., 2006, Int J Parasitol Link
CD8 Plasmodium berghei ANKA C57BL/6 → ↑d5-6 Potter et al., 2006, J Neuroimmunol Link
CD8 Plasmodium berghei K173 C57BL/6 → → Potter et al., 2006, Int J Parasitol Link

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