Platelets/serum amyloid P

Molecular group: 
Immune cells
Molecule/Cell: 
Platelets
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
5 x 10^5
Mouse genetic background (Con): 
C57BL/6J
Experimental treatment group (EG): 
+ anti-platelet (anti-GPIb) (day -1) + serum amyloid P (rSAP)
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (100%)
Parasitemia (EG vs Con): 
N.I.
Additional phenotypes (EG vs Con): 
Delayed mortality (days) compared to the platelet depleted mice without rSAP treatment
Refs: 
Aggrey et al., 2013, J Immunol