Molecular group:
Metabolic markers
Molecule/Cell:
Lactate
Plasmodium strain:
Plasmodium falciparum
Organ:
Blood
Population:
The Gambia
Transmission:
Stable
Adult/Pediatric:
Pediatric
SM† vs SM:
>
Patient number:
115
Additional differences:
Levels ↓ rapidly in survivors whereas levels ↓ slowly or even ↑ in fatal cases; concentrations between 4h and 24h were good predictors of a fatal outcome; + correlation with mortality, pyruvate concentrations, CSF lactate concentrations, blood TNF-a and IL-1a; - correlation with blood glucose concentration and clinical parameters of recovery; logistic regression indicated venous lactate ≥ 5 mmol/L (for CM CSF lactate > 4.5 mmol/L) as an independently predictive of fatal outcome
Refs:
Krishna et al., 1994, Trans R Soc Trop Med Hyg
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