Molecular group:
Leucocyte effector mechanisms and proteases
Molecule/Cell:
Caspase-12/caspase-1
Plasmodium strain:
Plasmodium chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
Casp12 -/- + selective caspase-1 inhibitor (YVAD)
Lethal infection (Con):
No
Lethal infection (EG):
No
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar serum IgG1 and ↑ IgG2a 21 days p.i. (similar compared to untreated infected casp12 -/- mice)
Refs:
Labbé et al., 2010, J Immunol
Hyperlink: