Mouse expression


The effects of malaria infection on expression levels (mRNA and protein) of cytokines, chemokines, enzymes, adhesion molecules, angiogenic and coagulation factors, metabolic molecules, etc. in different organs and body fluids of mice infected with different rodent malaria species are listed in this part of the database. For each molecule, information about the genetic background of the mouse strain, parasite species, inoculum size (pRBC), references (Refs), and a hyperlink to the original paper in the PubMed database (U.S. National Library of Medicine, National Institutes of Health) is included.

Dynamic fields: these are the columns that you can select to show in the output table. See also "How to use MalarImDB?" for more information.

Abbreviations: A, activity; ND, not detectable; N.I., not indicated; ns, not significant; ↑d, increased levels on day x (example1: ↑d4-8: levels increase from day 4 postinfection until day 8 postinfection; example2: ↑d4-…: levels increase from day 4 postinfection until end of observation time; example3: ↑d4, d8: levels are increased on day 4 postinfection and on day 8 postinfection)↓, decreased levels; →, similar levels (no changes)

 

SelectField
Full
Molecular group
Molecule/Cell
Plasmodium strain
pRBC infection titer
Mouse genetic background (Con)
Spleen mRNA
Spleen Protein
Liver mRNA
Liver protein
Brain mRNA
Brain protein
Lung mRNA
Lung protein
Kidney mRNA
Kidney protein
Heart protein
Pancreas protein
Mesentery protein
Thymus protein
Serum/plasma protein
Refs
PubMed
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Full Molecule/Cell Plasmodium strain Mouse genetic background (Con) Spleen mRNA Spleen Protein Liver mRNA Liver protein Brain mRNA Brain protein Lung mRNA Lung protein Kidney mRNA Kidney protein Serum/plasma protein Refs PubMed
TNF-a Plasmodium berghei ANKA C57BL/6 x 129 ↑d4, d8 Lucas et al., 1997, Eur J Immunol Link
TNF-a Plasmodium berghei ANKA C57BL/6J → ↑d5-6 Potter et al., 2006, J Neuroimmunol Link
TNF-a Plasmodium berghei ANKA C57BL/6J ↑ at time of CM Vigário et al., 2007, J Immunol Link
TNF-a Plasmodium berghei ANKA C57BL/6J ↑d8 ↑d8 Piguet et al., 2000, Infect Immun Link
TNF-a Plasmodium berghei ANKA C57BL/6J ↑d5 Morrell et al., 2011, Infect Immun Link
TNF-a Plasmodium berghei ANKA C57BL/6J ↑d8 Wiese et al., 2008, Malar J Link
TNF-a Plasmodium berghei ANKA C57BL/6J x 129/Ola ↑d7-10 (when CM symptoms manifested) Belnoue et al., 2003, Blood Link
TNF-a Plasmodium berghei ANKA CBA ↑d6 Ball et al., 2004, J Infect Dis Link
TNF-a Plasmodium berghei ANKA CBA ↑d6 ↑d5 Randall et al., 2008, Infect Immun Link
TNF-a Plasmodium berghei ANKA CBA/Ca ↑d7-8 Grau et al., 1987, Science Link
TNF-a Plasmodium berghei ANKA CBA/J ↑d7 ↑d7 De Kossodo et al., 1993, J Immunol Link
TNF-a Plasmodium berghei ANKA CBA/J ↑d6-7 Kaiser et al., 2006, J Infect Dis Link
TNF-a Plasmodium berghei ANKA CBA/J ↑d7 Kossodo et al., 1997, Immunology Link
TNF-a Plasmodium berghei ANKA CBA/J ↑d7 Penet at al., 2008, Proc Natl Acad Sci U S A Link
TNF-a Plasmodium berghei ANKA CBA/NSlc ↑d1, d9 ↑d9 Chen et al., 2000, Clin Exp Immunol Link
TNF-a Plasmodium berghei ANKA CBA/T6 ↑d6 Rae et al., 2004, FASEB J Link
TNF-a Plasmodium berghei ANKA DBA/1 ↑d8 Combes et al., 2005, Am J Pathol Link
TNF-a Plasmodium berghei ANKA 6653 Swiss Albino ↑d7 Dogruman-Al et al., 2009, New Microbiol Link
TNF-a Plasmodium berghei K173 C57BL/6 ↑d14 Ball et al., 2004, J Infect Dis Link
TNF-a Plasmodium berghei K173 C57BL/6 → → Potter et al., 2006, Int J Parasitol Link
TNF-a Plasmodium berghei K173 C57BL/6 ↑d7-10 Hermsen et al., 1997, Parasite Immunol Link
TNF-a Plasmodium berghei K173 CBA/T6 ↑d14 Rae et al., 2004, FASEB J Link
TNF-a Plasmodium berghei NK65 BALB/c ↑d3-10 Omer et al., 1998, J Exp Med Link
TNF-a Plasmodium berghei NK65 C57BL/6 ↑d2-12 ↑d2-12 Yoshimoto et al., 1998, J Immunol Link
TNF-a Plasmodium berghei NK65 C57BL/6J ↑d8-12 Van den steen et al., 2010, Am J Respir Crit Care Med Link
TNF-a Plasmodium chabaudi chabaudi AS (BALB/c x C57BL/6) F1 ↑d1-12 De Souza et al., 1997, Infect Immun Link
TNF-a Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 ↑d8 → Delic et al., 2010, Infect Immun Link
TNF-a Plasmodium chabaudi chabaudi AS A/J ↑d5 ↑d5-9 ↑d7-10 Jacobs et al., 1996, Infect Immun Link
TNF-a Plasmodium chabaudi chabaudi AS A/J ↑d7 Stevenson et al., 1995, J Immunol Link
TNF-a Plasmodium chabaudi chabaudi AS B10.D2 → ↑d4-… Cross et al., 1998, Exp Parasitol Link
TNF-a Plasmodium chabaudi chabaudi AS BALB/c ↑d6-9 Seixas et al., 2005, Exp Parasitol Link
TNF-a Plasmodium chabaudi chabaudi AS C57BL/6 ↑d6-14 Clark et al., 2007, Parasite Immunol Link
TNF-a Plasmodium chabaudi chabaudi AS C57BL/6 ↑d3-7, ↓d11-14 ↑d5-9 ↑d7-10 Jacobs et al., 1996, Infect Immun Link
TNF-a Plasmodium chabaudi chabaudi AS C57BL/6 ↑d7 Su et al., 2000, Infect Immun Link
TNF-a Plasmodium chabaudi chabaudi AS C57BL/6 ↑d7 Labbé et al., 2010, J Immunol Link
TNF-a Plasmodium chabaudi chabaudi AS C57BL/6 x 129 → Riopel et al., 2001, Infect Immun Link
TNF-a Plasmodium chabaudi chabaudi AS C57BL/6J ↑d12 Van den steen et al., 2010, Am J Respir Crit Care Med Link
TNF-a Plasmodium chabaudi chabaudi AS C57BL/6J ↑d7 Wykes et al., 2007, J Immunol Link
TNF-a Plasmodium chabaudi chabaudi AS DBA/2 → ↑d6-10 Cross et al., 1998, Exp Parasitol Link
TNF-a Plasmodium chabaudi chabaudi AS DBA/2 ↑d6-9 Seixas et al., 2009, Proc Natl Acad Sci U S A Link
TNF-a Plasmodium chabaudi chabaudi AS DBA/2 ↑d6-9 Seixas et al., 2005, Exp Parasitol Link
TNF-a Plasmodium vinckei (N.I.) C57BL/6J ↓d4, ↑d7 Wykes et al., 2007, J Immunol Link
TNF-a Plasmodium yoelii (N.I.) CBA/Ca → Grau et al., 1987, Science Link
TNF-a Plasmodium yoelii 17XL (BALB/c x C57BL/6) F1 ↑d3-7 De Souza et al., 1997, Infect Immun Link
TNF-a Plasmodium yoelii 17XL C57BL/6 ↑d7 Omer et al., 2003, J Immunol Link
TNF-a Plasmodium yoelii 17XL SW ↑d4-6 Shear et al., 1998, Am J Trop Med Hyg Link
TNF-a Plasmodium yoelii 17XNL (BALB/c x C57BL/6) F1 ↑d1, 5-21 De Souza et al., 1997, Infect Immun Link
TNF-a Plasmodium yoelii 17XNL C57BL/6 ↑d3-10 Omer et al., 2003, J Immunol Link
TNF-a Plasmodium yoelii 17XNL C57BL/6J → Wykes et al., 2007, J Immunol Link
TNF-a Plasmodium yoelii 17XNL SW ↑d8-20 Shear et al., 1998, Am J Trop Med Hyg Link
TNF-a Plasmodium yoelii 265 BALB/c ND ↑d11-13 Singh et al., 2002, J Immunol Link
TNFR1 Plasmodium berghei ANKA BALB/c → → Lucas et al., 1997, J Neuroimmunol Link
TNFR1 Plasmodium berghei ANKA C57BL/6 ↑d6 Randall et al., 2008, Infect Immun Link
TNFR1 Plasmodium berghei ANKA CBA ↑d6 Randall et al., 2008, Infect Immun Link
TNFR1 Plasmodium berghei ANKA CBA/Ca → → Lucas et al., 1997, J Neuroimmunol Link
TNFR1 Plasmodium berghei ANKA CBA/T6 ↑d6 Rae et al., 2004, FASEB J Link
TNFR1 Plasmodium berghei K173 C57BL/6J ↑d7-10 Hermsen et al., 1997, Parasite Immunol Link
TNFR1 Plasmodium berghei K173 CBA/T6 ↑d14 Rae et al., 2004, FASEB J Link
TNFR2 Plasmodium berghei ANKA BALB/c → → Lucas et al., 1997, J Neuroimmunol Link
TNFR2 Plasmodium berghei ANKA C57BL/6 ↑d6 Randall et al., 2008, Infect Immun Link
TNFR2 Plasmodium berghei ANKA CBA ↑d6 Randall et al., 2008, Infect Immun Link
TNFR2 Plasmodium berghei ANKA CBA/Ca ↑d8 → Lucas et al., 1997, J Neuroimmunol Link
TNFR2 Plasmodium berghei ANKA CBA/T6 ↑d6 Rae et al., 2004, FASEB J Link
TNFR2 Plasmodium berghei K173 C57BL/6J ↑d7-10 Hermsen et al., 1997, Parasite Immunol Link
TNFR2 Plasmodium berghei K173 CBA/T6 ↑d14 Rae et al., 2004, FASEB J Link
Total IgG Plasmodium chabaudi chabaudi AS BALB/c ↑d9-... Seixas et al., 2005, Exp Parasitol Link
Total IgG Plasmodium chabaudi chabaudi AS DBA/2 ↑d9-... Seixas et al., 2005, Exp Parasitol Link
Total IgM Plasmodium chabaudi chabaudi AS BALB/c ↑d7-... Seixas et al., 2005, Exp Parasitol Link
Total IgM Plasmodium chabaudi chabaudi AS DBA/2 ↑d9-... Seixas et al., 2005, Exp Parasitol Link
Tryptophan (Trp) Plasmodium berghei ANKA CBA/T6 ↑d6-7 → → Sanni et al., 1998, Am J Pathol Link
Tryptophan (Trp) Plasmodium berghei K173 CBA/T6 ↑d6-7, d14-15 ↑d14-15 → Sanni et al., 1998, Am J Pathol Link
UGT1A1 Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 ns Delic et al., 2010, Infect Immun Link
Uric acid Plasmodium berghei ANKA CBA/T6 ↑d7 Sanni et al., 1999, J Infect Dis Link
Uric acid Plasmodium berghei K173 CBA/T6 ↑d14-17 Sanni et al., 1999, J Infect Dis Link
VDR Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 ns Delic et al., 2010, Infect Immun Link
VEGF Plasmodium berghei ANKA BALB/c → Epiphanio et al., 2010, PLoS Pathog Link
VEGF Plasmodium berghei ANKA C57BL/6 → Epiphanio et al., 2010, PLoS Pathog Link
VEGF Plasmodium berghei ANKA DBA/2 ↑d7ALI; →HP → → → ↑d7ALI; →HP Epiphanio et al., 2010, PLoS Pathog Link
VEGF Plasmodium berghei NK65 DBA/2 → Epiphanio et al., 2010, PLoS Pathog Link
VEGF Plasmodium chabaudi chabaudi AS DBA/2 → Epiphanio et al., 2010, PLoS Pathog Link
VEGF Plasmodium yoelii 17X DBA/2 → Epiphanio et al., 2010, PLoS Pathog Link
vWF Plasmodium berghei ANKA C57BL/6 → Van der Heyde et al., 2005, Blood Link
XCL1 (lymphotactin) Plasmodium berghei ANKA CBA/T6 → Miu et al., 2008, J Immunol Link
XCL1 (lymphotactin) Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
XCR1 Plasmodium berghei ANKA CBA/T6 ↑d6 Miu et al., 2008, J Immunol Link
XCR1 Plasmodium berghei K173 CBA/T6 → Miu et al., 2008, J Immunol Link
µ-calpain Plasmodium berghei ANKA Swiss ↑d7-16 Shukla et al., 2006, Neurochem Int Link

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