Mouse expression


The effects of malaria infection on expression levels (mRNA and protein) of cytokines, chemokines, enzymes, adhesion molecules, angiogenic and coagulation factors, metabolic molecules, etc. in different organs and body fluids of mice infected with different rodent malaria species are listed in this part of the database. For each molecule, information about the genetic background of the mouse strain, parasite species, inoculum size (pRBC), references (Refs), and a hyperlink to the original paper in the PubMed database (U.S. National Library of Medicine, National Institutes of Health) is included.

Dynamic fields: these are the columns that you can select to show in the output table. See also "How to use MalarImDB?" for more information.

Abbreviations: A, activity; ND, not detectable; N.I., not indicated; ns, not significant; ↑d, increased levels on day x (example1: ↑d4-8: levels increase from day 4 postinfection until day 8 postinfection; example2: ↑d4-…: levels increase from day 4 postinfection until end of observation time; example3: ↑d4, d8: levels are increased on day 4 postinfection and on day 8 postinfection)↓, decreased levels; →, similar levels (no changes)

 

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Full
Molecular group
Molecule/Cell
Plasmodium strain
pRBC infection titer
Mouse genetic background (Con)
Spleen mRNA
Spleen Protein
Liver mRNA
Liver protein
Brain mRNA
Brain protein
Lung mRNA
Lung protein
Kidney mRNA
Kidney protein
Heart protein
Pancreas protein
Mesentery protein
Thymus protein
Serum/plasma protein
Refs
PubMed
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Full Molecule/Cell Plasmodium strain Mouse genetic background (Con) Spleen mRNA Spleen Protein Liver mRNA Liver protein Brain mRNA Brain protein Lung mRNA Lung protein Kidney mRNA Kidney protein Serum/plasma protein Refs PubMed
IFN-g Plasmodium chabaudi chabaudi AS C57BL/6 ↑d6-8 Clark et al., 2007, Parasite Immunol Link
IFN-g Plasmodium chabaudi chabaudi AS C57BL/6 ↑d3-9 Jacobs et al., 1996, Infect Immun Link
IFN-g Plasmodium chabaudi chabaudi AS C57BL/6 ↑d5-12 Su et al., 2002, J Immunol Link
IFN-g Plasmodium chabaudi chabaudi AS C57BL/6 x 129 ↑d7 Riopel et al., 2001, Infect Immun Link
IFN-g Plasmodium chabaudi chabaudi AS C57BL/6J ↑d8-12 Van den steen et al., 2010, Am J Respir Crit Care Med Link
IFN-g Plasmodium chabaudi chabaudi AS DBA/2 ↑d2, d6-8 ↑d6-8 Cross et al., 1998, Exp Parasitol Link
IFN-g Plasmodium yoelii 17XL (BALB/c x C57BL/6) F1 ↑d5 De Souza et al., 1997, Infect Immun Link
IFN-g Plasmodium yoelii 17XL BALB/cCr ↑d5 Ishih et al., 2004, Parasitol Res Link
IFN-g Plasmodium yoelii 17XL C57BL/6 ↑d2-7 Omer et al., 2003, J Immunol Link
IFN-g Plasmodium yoelii 17XNL (BALB/c x C57BL/6) F1 ↑d1, 5-21 De Souza et al., 1997, Infect Immun Link
IFN-g Plasmodium yoelii 17XNL C57BL/6 ↑d1-… Omer et al., 2003, J Immunol Link
IFN-g Plasmodium yoelii 265 BALB/c ↑d5-21 ↑d3-21 ↑d7-21 Singh et al., 2002, J Immunol Link
IFN-gR Plasmodium berghei ANKA CBA/T6 ↑d6 Rae et al., 2004, FASEB J Link
IFN-gR Plasmodium berghei K173 CBA/T6 ↑d14 Rae et al., 2004, FASEB J Link
IL-10 Plasmodium berghei ANKA 129Sv/Ev ↑d7 ↑d7 Amani et al., 2000, Eur J Immunol Link
IL-10 Plasmodium berghei ANKA BALB/c ↑d1, d9 ND Chen et al., 2000, Clin Exp Immunol Link
IL-10 Plasmodium berghei ANKA BALB/c → ↓d8 Kossodo et al., 1997, Immunology Link
IL-10 Plasmodium berghei ANKA C57BL/6 → Van der Heyde et al., 2005, Blood Link
IL-10 Plasmodium berghei ANKA C57BL/6 ↑d7 ↑d5 Beghdadi et al., 2008, J Exp Med Link
IL-10 Plasmodium berghei ANKA C57BL/6 ↑d3-6 Mitchell et al., 2005, Infect Immun Link
IL-10 Plasmodium berghei ANKA C57BL/6 ↑d5 Randall et al., 2008, Infect Immun Link
IL-10 Plasmodium berghei ANKA C57BL/6 → De Miranda et al., 2011, Neurosci Lett Link
IL-10 Plasmodium berghei ANKA C57BL/6 ↑d11 ↑d11 ↑d8-11 Tan et al., 2000 Parasite Immunol Link
IL-10 Plasmodium berghei ANKA C57BL/6 ↑d5 Higgins et al., 2013, Malar J Link
IL-10 Plasmodium berghei ANKA C57BL/6 x 129/Ola ↑d7-10 (when CM symptoms manifested) Belnoue et al., 2003, Blood Link
IL-10 Plasmodium berghei ANKA CBA ↑d5 Randall et al., 2008, Infect Immun Link
IL-10 Plasmodium berghei ANKA CBA/J ↑d8 → Kossodo et al., 1997, Immunology Link
IL-10 Plasmodium berghei ANKA CBA/NSlc ↑d1, d9 ND Chen et al., 2000, Clin Exp Immunol Link
IL-10 Plasmodium berghei ANKA + K173 C57BL/6 ↑d1 Mitchell et al., 2005, Infect Immun Link
IL-10 Plasmodium berghei ANKA 6653 Swiss Albino ↑d7 Dogruman-Al et al., 2009, New Microbiol Link
IL-10 Plasmodium berghei K173 C57BL/6 ↑d1-2, d4-10 Mitchell et al., 2005, Infect Immun Link
IL-10 Plasmodium berghei NK65 BALB/c → Omer et al., 1998, J Exp Med Link
IL-10 Plasmodium berghei NK65 C57BL/6 ↑d4-12 ↓d2, ↑d4-12 Yoshimoto et al., 1998, J Immunol Link
IL-10 Plasmodium berghei NK65 C57BL/6J ↑d8-12 Van den steen et al., 2010, Am J Respir Crit Care Med Link
IL-10 Plasmodium berghei XAT CBA/JNCrj ↑d4-12 Yoshimoto et al., 1998, J Infect Dis Link
IL-10 Plasmodium chabaudi chabaudi AS C57BL/6 ↑d6-7 Labbé et al., 2010, J Immunol Link
IL-10 Plasmodium chabaudi chabaudi AS C57BL/6J ↑d8-12 Van den steen et al., 2010, Am J Respir Crit Care Med Link
IL-10 Plasmodium yoelii 17XL C57BL/6 ↑d5-7 Omer et al., 2003, J Immunol Link
IL-10 Plasmodium yoelii 17XNL C57BL/6 ↑d5-… Omer et al., 2003, J Immunol Link
IL-12 Plasmodium berghei ANKA C57BL/6 ND Mitchell et al., 2005, Infect Immun Link
IL-12 Plasmodium berghei ANKA C57BL/6 ↑d5 Higgins et al., 2013, Malar J Link
IL-12 Plasmodium berghei ANKA + K173 C57BL/6 ↑d1 Mitchell et al., 2005, Infect Immun Link
IL-12 Plasmodium berghei ANKA 6653 Swiss Albino ↑d7 Dogruman-Al et al., 2009, New Microbiol Link
IL-12 Plasmodium berghei K173 C57BL/6 ↑d1 Mitchell et al., 2005, Infect Immun Link
IL-12p35 Plasmodium berghei NK65 C57BL/6 → ↑d4, d8, d12 Yoshimoto et al., 1998, J Immunol Link
IL-12p35 Plasmodium berghei XAT CBA/JNCrj → Yoshimoto et al., 1998, J Infect Dis Link
IL-12p40 Plasmodium berghei ANKA BALB/c ↑d1, d9 ↑d9 Chen et al., 2000, Clin Exp Immunol Link
IL-12p40 Plasmodium berghei ANKA BALB/c ↑d3-11 ↑d3-11 Singh et al., 2002, J Immunol Link
IL-12p40 Plasmodium berghei ANKA CBA/NSlc ↑d1, d9 ↑d9 Chen et al., 2000, Clin Exp Immunol Link
IL-12p40 Plasmodium berghei NK65 C57BL/6 ↑d3-4 Adachi et al., 2001, J Immunol Link
IL-12p40 Plasmodium berghei NK65 C57BL/6 ↑d2-8 ↑d2-12 Yoshimoto et al., 1998, J Immunol Link
IL-12p40 Plasmodium berghei XAT CBA/JNCrj ↑d2-12 ↑d2-12 Yoshimoto et al., 1998, J Infect Dis Link
IL-12p40 Plasmodium yoelii 265 BALB/c ↑d3-17 ↑d3-21 Singh et al., 2002, J Immunol Link
IL-12p70 Plasmodium berghei (N.I.) C57BL/6 ↓d4, d7 Wykes et al., 2007, J Immunol Link
IL-12p70 Plasmodium chabaudi chabaudi AS BALB/c ↑d6-9 Seixas et al., 2005, Exp Parasitol Link
IL-12p70 Plasmodium chabaudi chabaudi AS C57BL/6 ↑d2 Su et al., 2000, Infect Immun Link
IL-12p70 Plasmodium chabaudi chabaudi AS C57BL/6J ↑d7 Wykes et al., 2007, J Immunol Link
IL-12p70 Plasmodium chabaudi chabaudi AS DBA/2 ↑d6-9 Seixas et al., 2005, Exp Parasitol Link
IL-12p70 Plasmodium vinckei (N.I.) C57BL/6J ↓d4, d7 Wykes et al., 2007, J Immunol Link
IL-12p70 Plasmodium yoelii 17XNL C57BL/6J ↑d7 Wykes et al., 2007, J Immunol Link
IL-18 Plasmodium berghei ANKA BALB/c ↑d3-7 ↑d5-9 Singh et al., 2002, J Immunol Link
IL-18 Plasmodium berghei ANKA C57BL/6 ↑d6 Gramaglia et al., 2006, Nat Med Link
IL-18 Plasmodium berghei ANKA C57BL/6 → Mitchell et al., 2005, Infect Immun Link
IL-18 Plasmodium berghei ANKA C57BL/6 ↑d6-8 Singh et al., 2002, J Immunol Link
IL-18 Plasmodium berghei K173 C57BL/6 → Mitchell et al., 2005, Infect Immun Link
IL-18 Plasmodium berghei NK65 C57BL/6 ↑d4-7 Adachi et al., 2001, J Immunol Link
IL-18 Plasmodium chabaudi chabaudi AS C57BL/6 → Labbé et al., 2010, J Immunol Link
IL-18 Plasmodium yoelii 265 BALB/c ND ↑d5-11 Singh et al., 2002, J Immunol Link
IL-1a Plasmodium berghei ANKA BALB/c ND ↑d7 De Kossodo et al., 1993, J Immunol Link
IL-1a Plasmodium berghei ANKA CBA/J ND ↑d7 De Kossodo et al., 1993, J Immunol Link
IL-1b Plasmodium berghei ANKA C57BL/6 ↑d1-6 Finney et al., 2009, Am J Trop Med Hyg Link
IL-1b Plasmodium berghei ANKA C57BL/6 ↑d5 De Miranda et al., 2011, Neurosci Lett Link
IL-1b Plasmodium berghei ANKA C57BL/6 → Labbé et al., 2010, J Immunol Link
IL-1b Plasmodium berghei ANKA C57BL/6J ↑d8 Wiese et al., 2008, Malar J Link
IL-1b Plasmodium berghei ANKA CBA ↑d6 Ball et al., 2004, J Infect Dis Link
IL-1b Plasmodium berghei K173 CBA ↑d14 Ball et al., 2004, J Infect Dis Link
IL-1b Plasmodium berghei NK65 C57BL/6J ↑d10 Van den steen et al., 2010, Am J Respir Crit Care Med Link
IL-1b Plasmodium chabaudi chabaudi AS 129/SvJ x C57BL/6 ↑d8 ↑d8 Delic et al., 2010, Infect Immun Link
IL-2 Plasmodium berghei ANKA BALB/c ↑d1, d9 ↑d9 Chen et al., 2000, Clin Exp Immunol Link
IL-2 Plasmodium berghei ANKA BALB/c ↑d7 Singh et al., 2002, J Immunol Link
IL-2 Plasmodium berghei ANKA C57BL/6 ↑d4 Van der Heyde et al., 2005, Blood Link
IL-2 Plasmodium berghei ANKA CBA/NSlc ↑d1, d9 ↑d9 Chen et al., 2000, Clin Exp Immunol Link
IL-2 Plasmodium yoelii 265 BALB/c ↑d9 Singh et al., 2002, J Immunol Link
IL-3 Plasmodium chabaudi chabaudi AS BALB/c ↑d12-15 Helmby et al., 1998, Eur J Immunol Link
IL-4 Plasmodium berghei ANKA (BALB/c x C57BL/6) F1 ↑d5-15 De Souza et al., 1997, Infect Immun Link
IL-4 Plasmodium berghei ANKA BALB/c ↑d9 ND Chen et al., 2000, Clin Exp Immunol Link
IL-4 Plasmodium berghei ANKA BALB/c ↓d7 → De Kossodo et al., 1993, J Immunol Link
IL-4 Plasmodium berghei ANKA BALB/c → Singh et al., 2002, J Immunol Link
IL-4 Plasmodium berghei ANKA C57BL/6 ns Beghdadi et al., 2008, J Exp Med Link
IL-4 Plasmodium berghei ANKA C57BL/6 → De Miranda et al., 2011, Neurosci Lett Link
IL-4 Plasmodium berghei ANKA CBA/J ↓d7 (ND) ↓d7 (ND) De Kossodo et al., 1993, J Immunol Link
IL-4 Plasmodium berghei ANKA CBA/NSlc ↑d9 ND Chen et al., 2000, Clin Exp Immunol Link
IL-4 Plasmodium berghei ANKA 6653 Swiss Albino ↑d7 Dogruman-Al et al., 2009, New Microbiol Link
IL-4 Plasmodium berghei NK65 BALB/c → Omer et al., 1998, J Exp Med Link
IL-4 Plasmodium berghei NK65 C57BL/6 ↑d2-10 ↑d4-8, d12 Yoshimoto et al., 1998, J Immunol Link
IL-4 Plasmodium berghei XAT CBA/JNCrj ↑d2-12 Yoshimoto et al., 1998, J Infect Dis Link
IL-4 Plasmodium chabaudi chabaudi AS (BALB/c x C57BL/6) F1 ↑d5-12 De Souza et al., 1997, Infect Immun Link
IL-4 Plasmodium chabaudi chabaudi AS A/J ↑d5-9 Jacobs et al., 1996, Infect Immun Link
IL-4 Plasmodium chabaudi chabaudi AS C57BL/6 ↑d3-7 Jacobs et al., 1996, Infect Immun Link
IL-4 Plasmodium yoelii 17XL (BALB/c x C57BL/6) F1 ↑d5-7 De Souza et al., 1997, Infect Immun Link

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